Insulin-like Growth Factor-1 lr3 – IGF-1 LR3 The Immense Growth Factor In Muscle Building.
IGF-1 (Insulin-like growth factor) is an endocrine hormone that is produced in the liver. The production of IGF-1 is increased in the presence of growth hormone. IGF stands for insulin-like growth factor. Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin . It plays an important role in childhood growth and continues to have effects in adults. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.
Why is this IGF-1 important for a bodybuilder or athlete? Let’s take a look at the list:
- Helps regulate fat for use as energy, resulting in fat loss.
- Contributes to anti aging. As we get older, IGF-1 production slows down and this results in cell reduction. Low levels of IGF-1 are linked to heart failure, lower brain cell regulation and neuron function. Not to mention muscle tissue breakdown.
- Helps to increase nutrient shuttling (protein synthesis).
- Increases regenerative functions of nerve tissues.
- Boosts the ability to cause hyperplasia in muscle cells resulting in fuller muscle tissue.
LR-3 IGF-1 Application:
-average 14% of fat decrease
-average 8.8% increase the structures of the body and lean muscle
-Improved skin texture resulting in a more youthful appearance
-Remove the wrinkles from skin
-Increased bone density, stopped osteoporosis
-Faster healing of any type of injury, fracture, or wound
-Significantly increased immunity and resistance to infection
-Increased brain function, retention of intellect with aging
-Improvement of Alzheimer and Parkinson syndromes
-Improved sex drive
-The improvement in the fullest physical and mental well-being
-Improved training tolerance
-Improved mood, less depression and fatigue
-Improved heart and kidney function
-Large cardiac output
-Anti – aging
-Any cases of diabetes
To put it simply, the gains from IGF-1 (all variants) are not due to water weight, so the gains you will achieve will be long term muscle growth. This is compared to steroids, which are renowned for putting on water weight and giving you nasty side effects. You are not going to gain 10lbs from using IGF-1, but you will see solid 1-2lbs gains every 1-2 weeks.
The most important factor to consider is IGF-1’s ability to achieve hyperplasia. When you use steroids, they will help the body through hypertrophy, which means you are increasing the size of the existing muscle cells. On the other hand, IGF-1 will cause hyperplasia, which means you are actually increasing the number of cells in the muscle tissue. These new cells can be utilized through further training, and use of steroids, to make bigger muscles. Essentially, you will have the ability to achieve more muscle density and size at the genetic level by using IGF-1.
IGF-1 variants are split into two groups: IGF-1 LR3 and DES IGF-1 (usually presented as IGF-1 DES). Base IGF-1 has a very short half life (about 10-20 minutes); as a result, it is quickly destroyed by the body. This is why IGF-1 was modified to make the amino acid analog IGF-1 LR3 (Long). The other variant of IGF-1 called DES IGF-1 is a truncated version that is 10X more potent than IGF-1. Both variants are similar to its root but have different actions, allowing them to function in a specific ways.
Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue ofhuman insulin-like growth factor 1 (IGF-1). IGF-1 LR3has a half-life of about 20-30 hours and is much more potent than base IGF-1. Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.
LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren’t necessary, as IGF-1 LR3 will cycle the body binding to all muscle cells for about a day.
Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF’s.
The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.
DES IGF-1is the shorter version of the IGF-1 chain.Not worth The trouble to run compared with Lr3 IGF-1
IGF-1 Cycle, Dosing and Injections:
The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage.
The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on.
IGF-1 LR3 can be taken 7 days a week at a dose of 50-150mcg a day. Desensitization was shown to occur at around 40 days or roughly 4 weeks. Injection sites can be at any muscle group on the body, as it’s not very good at site specific growth.
DES IGF-1 can be dosed at 50-150mcg multiple times a day (prior to training) into specific target areas. since DES has such a short half life (20-30 minutes), desensitization was not noticed at all . Injection sites should be localized; preferably, at the muscle group you want to grow. In simple terms, if you want to grow your biceps, inject IGF-1 DES right into your bicep.
IGF-1 Side Effects:
It should be noted that high doses of IGF-1 have been known to cause hypoglycemia, but nowhere near the level of insulin. It is also noted, and highly debated, that IGF-1 was shown to increase tumor size in cancer patients. While this fact may be true in patients with existing cancer, IGF-1 is not the cause of cancer; in fact, our bodies need IGF-1 to regulate heart function, nervous system and brain cell stimulation. People with low IGF-1 levels were found to have low protein counts and low lean body mass, which, in turn, can be equally unhealthy. If you have a headache, you don’t take a whole bottle of Aspirin. Likewise, to guard yourself from making ignorant mistakes, IGF-1 should be administered properly , and never abused.
IGF-1 LR3 Pictures
Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) is an 83 amino acid analog of IGF-I comprising the complete IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Long-R3-IGF-I is significantly more potent than IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs.
1. Swab the top of your sterile vial with alcohol prep pad (70% isopropyl alcohol)
2. Mix 7.5mL distilled water with 1.0mL vinegar
3. Add Whatman syringe filter
4. Add sterile ~20ga. needle to end of Whatman filter
5. Inject the 8.5mL of solution into the sterile vial
6. You now have sterile 0.6% acetic acid
IGF-1 LR3 – Reconstituted Versus Lyophilization:
Fifteen Years ago, when athletes and bodybuilders became aware of this new form of IGF 1 pateneted by Gropep their was not a lot of information on it by way of studies or personal experience shared on the online discussion forums like MuscleChemistry.com . As of today October 28th 2018 you will still find many antiquated articles on how to use this particular growth factor as well as well as what to look for to make sure your igf-1 lr3 is going to be delivered to you with 100% viability. So when reading online articles on anything really but specifically IGF 1 lr3 try to look for the date the article was submitted! Thats not to say the information is always no good , but in this particular field of peptides and bio engineering and bio-hacking age, a lot changes fast!
Take for instance, the fact that it use to be that this Lr3 IGF 1 was only supplied in Lyophilized form, and it was patented, so not a lot of reproducing it and altering to the molecule was done back then, fast forward to taoday and we now have different varients of this growth factor, and it now is supplied in both lyophilzed form and already reconstituted form straight from the manufacturer !
Up until just a few years ago, you would have to purchase 50mg or 100mg of lyophilzed IGF 1 lr3 which came in just one big 100ml or 50 ml size vial. It didnt look like much when you received it either, and had you have not known youpurchased it from a legit company like Gropep , you would have thought you were being had. Slowly you were able to find IGF 1 lr3 through other bio-pharmaceutical vendors, such as Cell Sciences, Sigma aldrich and the list grew and grew over the years into what we have now today, a vendor and manufacturer in every corner of the globe, making it easier to ascertain than it was previously when you needed to biy it straight from Australia (gropep) and worry about it making it to you unscathed!